ABSTRACT
Objective To observe the therapeutic effect of Taoshi Jiangu Decoction for osteoporosis(OP). Methods A total of 120 cases of OP patients were randomly divided into treatment group and control group ,60 cases in each group. Patients in the treatment group were treated with Taoshi Jiangu Decoction orally,and those in the control group were treated with Caltrate D and Alendronate Sodium Tablets orally. Four weeks constituted one treatment course, and the treatment for the two groups covered 3 courses. The therapeutic effect of the two groups was evaluated by the changes of traditional Chinese medicine(TCM)syndrome scores,urine hydroxyproline (U-HYP),serum bone Gla-protein (BGP or osteocalcin),serum alkaline phosphatase (ALP),urine calcium (U-Ca),tartrate resistant acid phosphatase (TRAP), bone mass density(BMD) and quantitative CT(QCT) before and after treatment. Results (1)After treatment, the TCM syndrome scores of the two groups were decreased(P<0.05 compared with those before treatment),and the decrease in the treatment group was superior to that of the control group (P < 0.05). (2)After treatment,the levels of bone formation indexes of ALP and BGP were increased,and the levels of bone resorption indexes of U-HYP,U-Ca and TRAP were decreased in the two groups (P<0.05 compared with those before treatment). The effects of the treatment group were superior to those of the control group,the difference being statistically significant(P < 0.05).(3)After treatment,BMD of lumbar vertebrae 2-4 (L2-L4),neck of femur,Wards triangle and trochanter of femur,and QCT values of left neck of femur were obviously increased in the two groups (P < 0.05 compared with those before treatment). The treatment group showed stronger effect on increasing BMD and QCT values than the control group, the difference being statistically significant (P < 0.05). Conclusion Taoshi Jiangu Decoction can restrain bone absorption , promote bone formation and increase BMD, showing certain therapeutic effect for OP.
ABSTRACT
Objective To evaluate the effects of blood withdrawal from peripheral intravenous catheters (PIC) on blood samples via meta-analysis.Methods We performed a systematic search in Cochrane Library,PubMed,EBSCO,CINAHL,Embase,CMBdisc (China Biology Medicine disc),Wan Fang Data,VIP (China Science and Technology Journal Database),CNKI (China National Knowledge Infrastructure)to collect randomized controlled trails (RCTs)about the effects of blood withdrawal from peripheral intravenous catheters.The quality of RCTs was critically appraised and data were extracted by two reviewers independently.Meta-analysis was conducted for eligible RCTs.Results Totally 22 studies were retrieved and 7554 blood samples were included.Results of meta-analysis showed as compared with standard blood drawn by direct venipuncture (DVP),there was no significant risk of hemolysis rates of blood samples collected from PVC [random effect RR =2.01,95％ CI (1.01,4.00),P=0.05];with certain procedures,results of laboratory tests of blood samples withdrawal from PIC had little impacts on red blood cell count(RBC),white blood cell count(WBC),platelet count (PLT),fasting blood-glucose(FBG)and serum levels of sodium,potassium,calcium,chlorine,and the differences had no statistical significance (P＞0.05).Conclusion Blood samples withdrawal from PIC will not increase hemolysis if sampling after infusion has been stopped for 2～3 min and 2～5 ml blood is discharged,which are reliable for blood routine and biochemical tests.After a comprehensive consideration,the technique of blood withdrawal from a PIC could be used interchangeably from DVP.